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Base-Catalyzed One-Pot Synthesis of Indolizine-1-carboxylates Tethered to 2-Aroyl Benzofurans and Benzothiophenes
- Lee, Juyoung;
- Ahn, Sooseong;
- Eom, Kihyeon;
- Park, Younggeun;
- Lee, Kyeong;
- 외 2명
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0초록
Herein, we report a base-catalyzed one-pot synthesis of indolizine-1-carboxylates tethered to 2-aroyl benzofurans and benzothiophenes from 2-pyridin-2-ylacetates, DMF-DMA, and 2-aroyl-benzofuran/benzothiophene-3-methyl bromides. This protocol provides access to diverse indolizine derivatives in moderate to good yields under simple conditions. A broad range of substituents on both the benzofuran/benzothiophene and pyridine-2-ylacetate components was tolerated well, and gram-scale synthesis was achieved without chromatographic purification. In addition, postsynthetic Suzuki coupling of the bromine-containing products enabled the construction of highly conjugated indolizine-benzofuran architectures.
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BIOACTIVITY; INDOLIZINES
- 제목
- Base-Catalyzed One-Pot Synthesis of Indolizine-1-carboxylates Tethered to 2-Aroyl Benzofurans and Benzothiophenes
- 저자
- Lee, Juyoung; Ahn, Sooseong; Eom, Kihyeon; Park, Younggeun; Lee, Kyeong; Jalani, Hitesh B.; Choi, Yongseok
- 발행일
- 2026-04
- 유형
- Article
- 권
- 91
- 호
- 16
- 페이지
- 5713 ~ 5717