상세 보기
- Dey, Anwesha;
- Kumar, Ramesh;
- Dutta, Bhramar;
- Bandopadhyay, Rajib;
- Chakrabortty, Sankha;
- ... Saratale, Ganesh Dattatraya;
- 외 4명
WEB OF SCIENCE
3SCOPUS
3초록
Zn(II)-based anticancer drugs can be suitable alternatives to conventional Pt(II)-based drugs because of the unique chemical properties of Zn(II) and low toxicity. In this study, a new hexadentate and heteroleptic Zn(II) complex ([Zn(bpy)(2)(OAc)(2)], 1) was prepared with a conventional N,N-donor ligand (2,2 '-bipyridine) and a leaving group (OAc) and characterized via ESI-MS, UV-Vis, and FT-IR spectroscopy. Kinetic and mechanistic investigations of 1 were performed using two biologically relevant ligands (dl-penicillamine and l-cysteine) to understand its selectivity and reactivity. Substitution reactions were determined to be two-step processes in the associative activation mode. Bioactivity studies of 1 revealed moderate to strong DNA-binding, cleaving ability, and antimicrobial properties.
키워드
- 제목
- Synthesis, kinetics, mechanisms, and bioactivity evaluations of a novel Zn(II) complex
- 저자
- Dey, Anwesha; Kumar, Ramesh; Dutta, Bhramar; Bandopadhyay, Rajib; Chakrabortty, Sankha; Khan, Moonis Ali; Saratale, Rijuta Ganesh; Saratale, Ganesh Dattatraya; Jeon, Byong Hun; Ghosh, Alak K.
- 발행일
- 2024-09
- 유형
- Article
- 저널명
- RSC Advances
- 권
- 14
- 호
- 39
- 페이지
- 28693 ~ 28702