Efficacy of diphenylcyclopropenone immunotherapy for wart based on anatomical location

Abstract

Background: Despite the numerous treatment options for cutaneous warts, choosing the appropriate method for optimum results can be challenging. Treatment strategies should be individualized according to the patient and lesion characteristics. However, there is a paucity of research on the clinical factors predicting treatment response. Objective: To investigate the efficacy of diphenylcyclopropenone immunotherapy for warts, based on anatomical location Methods: This retrospective study included 262 wart lesions from 99 patients treated with diphenylcyclopropenone immunotherapy for warts between 2007 and 2018. The lesions were divided into three groups-periungual wart, palmoplantar wart, or hair-bearing skin wart-according to anatomical location. Periungual warts were divided into hyponychium, proximal nail fold, and lateral nail fold-type subgroups. Treatment success rates were compared between the groups. Results: The treatment success rate of periungual warts (75.3%) was significantly higher than those of palmoplantar (60.4%) and hair-bearing skin (60.3%) warts. No significant differences were observed between the treatment success rates of the periungual wart subgroups. Conclusion: Diphenylcyclopropenone immunotherapy is an effective treatment modality for periungual warts. © 2020 Korean Dermatological Association. All rights reserved.