Organic nanocomposite Band-Aid for chronic wound healing: a novel honey-based nanofibrous scaffold

Abstract

Honey is a natural medicine; incorporating it, a PVA/honey hybrid nanofibrous Band-Aid was fabricated by electrospinning technique, and the prepared electrospun scaffolds were characterized by UV-visible spectroscopy, FTIR spectroscopy and XRD techniques. The honey-adsorbed scaffolds showed UV-visible absorption at 306 nm wavelength expressing the presence of honey in polymer scaffold. In addition, it indicated that the honey was not degenerated even at the highest applied voltage of 16 kV given during electrospinning. Conductivity study of the scaffold revealed linear increase of conductivity as 0.74, 0.80, 0.82 and 0.83 mho with increase of honey concentration, which revealed the high honey releasing profile of the scaffolds at higher concentration. Efficiency of fabricated Band-Aids was analyzed by swelling character and in vitro releasing kinetics. The higher level of honey osmolality increased the fluid uptake into scaffolds and showed highest degree of swelling indicating an efficient release of honey by diffusion.