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CRISPR/dCAS9-DNMT3a에 의한 APP 유전자 프로모터 methylation 유도를 통한 알츠하이머 치매 치료방법Treatment of Alzheimer's disease based on methylation for APP promoter

Alternative Title
Treatment of Alzheimer's disease based on methylation for APP promoter
Authors
김종필박한슬신재인
URI
https://scholarworks.dongguk.edu/handle/sw.dongguk/62132
Abstract
dCas9과 DNA 메틸기전이효소의 일종인 Dnmt3a를 결합한 dCas9-dnmt3a가 APP 유전자 프로모터의 메틸화를 통해 APP 유전자만을 특이적으로 발현을 억제하는 시스템을 통해 완성하게 되었다. 이에, 본 발명의 목적은 알츠하이머 치매 뇌 내의 신경 세포에 CRISPR/dCas9-Dnmt3a를 이용하여 APP 유전자 발현을 억제하고, 이를 통해 알츠하이머 치매 치료방법을 제공하고자 한다.
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