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Targeted Discovery of an Enediyne-Derived Cycloaromatized Compound, Jejucarboside A, from a Marine Actinomycete

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dc.contributor.authorIm, Ji Hyeon-
dc.contributor.authorShin, Daniel-
dc.contributor.authorBan, Yeon Hee-
dc.contributor.authorByun, Woong Sub-
dc.contributor.authorBae, Eun Seo-
dc.contributor.authorLee, Donghoon-
dc.contributor.authorDu, Young Eun-
dc.contributor.authorCui, Jinsheng-
dc.contributor.authorKwon, Yun-
dc.contributor.authorNam, Sang-Jip-
dc.contributor.authorCha, Sangwon-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorYoon, Yeo Joon-
dc.contributor.authorOh, Dong-Chan-
dc.date.accessioned2023-04-27T13:41:17Z-
dc.date.available2023-04-27T13:41:17Z-
dc.date.issued2022-10-
dc.identifier.issn1523-7060-
dc.identifier.issn1523-7052-
dc.identifier.urihttps://scholarworks.dongguk.edu/handle/sw.dongguk/3858-
dc.description.abstractA genomic and spectroscopic signature-based search revealed a cycloaromatized enediyne, jejucarboside A (1), from a marine actinomycete strain. The structure of 1 was determined as a new cyclopenta[a]indene glycoside bearing carbonate functionality by nuclear magnetic resonance, high-resolution mass spectrometry (MS), MS/MS, infrared spectroscopy, and a modified Mosher's method. An iterative enediyne synthase pathway has been proposed for the putative biosynthesis of 1 by genomic analysis. Jejucarboside A exhibited cytotoxicity against the HCT116 colon carcinoma cells. © 2022 American Chemical Society. All rights reserved.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherAmerican Chemical Society-
dc.titleTargeted Discovery of an Enediyne-Derived Cycloaromatized Compound, Jejucarboside A, from a Marine Actinomycete-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1021/acs.orglett.2c02934-
dc.identifier.scopusid2-s2.0-85139178947-
dc.identifier.wosid000862944100001-
dc.identifier.bibliographicCitationOrganic Letters, v.24, no.39, pp 7188 - 7193-
dc.citation.titleOrganic Letters-
dc.citation.volume24-
dc.citation.number39-
dc.citation.startPage7188-
dc.citation.endPage7193-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordAuthorEnediynes-
dc.subject.keywordAuthorGlycosides-
dc.subject.keywordAuthorIndenes-
dc.subject.keywordAuthorEnediyne-
dc.subject.keywordAuthorGlycoside-
dc.subject.keywordAuthorIndene Derivative-
dc.subject.keywordAuthorActinobacteria-
dc.subject.keywordAuthorChemical Structure-
dc.subject.keywordAuthorChemistry-
dc.subject.keywordAuthorTandem Mass Spectrometry-
dc.subject.keywordAuthorEnediynes-
dc.subject.keywordAuthorGlycosides-
dc.subject.keywordAuthorIndenes-
dc.subject.keywordAuthorMolecular Structure-
dc.subject.keywordAuthorTandem Mass Spectrometry-
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