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Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystoniaopen access
- Authors
- Huang, Pei; Li, Yuan-Yuan; Park, Jung E.; Huang, Ping; Xiao, Qin; Wang, Ying; Chen, Sheng; Chen, Sheng-Di; Liu, Jun; Wu, Yi-Wen
- Issue Date
- Jan-2022
- Publisher
- Cambridge University Press
- Keywords
- Parkinson's disease; Foot dystonia; Botulinum toxin A; Gait
- Citation
- Canadian Journal of Neurological Sciences, v.49, no.1, pp 123 - 128
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Canadian Journal of Neurological Sciences
- Volume
- 49
- Number
- 1
- Start Page
- 123
- End Page
- 128
- ISSN
- 0317-1671
2057-0155
- Abstract
- We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.
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Related Researcher
- Park, Jung E
- Graduate School (Department of Medicine)