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Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viabilityopen access
- Authors
- Jang, Hye Min; Jung, Myung Hwan; Lee, Jae Sang; Lee, Jun Sig; Lim, In-Cheol; Im, Hyunsik; Kim, Sang Wook; Kang, Sung-A; Cho, Won-Je; Park, Jun Kue
- Issue Date
- Aug-2022
- Publisher
- MDPI
- Keywords
- superparamagnetic nanoparticles; magnetic relaxivity; PET-MRI; multimodal imaging; contrast agents; nanoparticles; silica core-shell
- Citation
- Nanomaterials, v.12, no.16, pp 1 - 11
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- Nanomaterials
- Volume
- 12
- Number
- 16
- Start Page
- 1
- End Page
- 11
- ISSN
- 2079-4991
2079-4991
- Abstract
- We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope Cu-64 may act as a contrast agent being a diagnostic tool for PET as well as a good T-2 MRI nanoprobe due to their good r(2)/r(1) ratio. Furthermore, we demonstrate that the Cu-64 incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.
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