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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yang, Jee Sun | - |
| dc.contributor.author | Song, Doona | - |
| dc.contributor.author | Ko, Won Jin | - |
| dc.contributor.author | Kim, Bunyea | - |
| dc.contributor.author | Kim, Bo-Kyung | - |
| dc.contributor.author | Park, Song-Kyu | - |
| dc.contributor.author | Won, Misun | - |
| dc.contributor.author | Lee, Kiho | - |
| dc.contributor.author | Lee, Kyeong | - |
| dc.contributor.author | Kim, Hwan Mook | - |
| dc.contributor.author | Han, Gyoonhee | - |
| dc.date.accessioned | 2024-09-25T03:32:07Z | - |
| dc.date.available | 2024-09-25T03:32:07Z | - |
| dc.date.issued | 2013-05 | - |
| dc.identifier.issn | 0223-5234 | - |
| dc.identifier.issn | 1768-3254 | - |
| dc.identifier.uri | https://scholarworks.dongguk.edu/handle/sw.dongguk/23722 | - |
| dc.description.abstract | A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells. (C) 2013 Elsevier Masson SAS. All rights reserved. | - |
| dc.format.extent | 8 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
| dc.title | Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II | - |
| dc.type | Article | - |
| dc.publisher.location | 프랑스 | - |
| dc.identifier.doi | 10.1016/j.ejmech.2012.12.063 | - |
| dc.identifier.scopusid | 2-s2.0-84875932912 | - |
| dc.identifier.wosid | 000322855400059 | - |
| dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.63, pp 621 - 628 | - |
| dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| dc.citation.volume | 63 | - |
| dc.citation.startPage | 621 | - |
| dc.citation.endPage | 628 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.subject.keywordPlus | RHOB EXPRESSION | - |
| dc.subject.keywordPlus | RAS TRANSFORMATION | - |
| dc.subject.keywordPlus | PROTEIN-KINASES | - |
| dc.subject.keywordPlus | HUMAN CANCER | - |
| dc.subject.keywordPlus | APOPTOSIS | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.subject.keywordPlus | INHIBITORS | - |
| dc.subject.keywordAuthor | Aliphatic amido-quaternary ammonium salts | - |
| dc.subject.keywordAuthor | Open-ring form of aliphatic amido-quaternary ammonium salts | - |
| dc.subject.keywordAuthor | RhoB | - |
| dc.subject.keywordAuthor | GTPase RAt Sarcoma (Ras) | - |
| dc.subject.keywordAuthor | Perifosine | - |
| dc.subject.keywordAuthor | NSC126188 | - |
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Related Researcher
- Lee, Kyeong
- College of Pharmacy (Department of Pharmacy)