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Cited 16 time in webofscience Cited 17 time in scopus
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Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers

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dc.contributor.authorSingh, Sarbjit-
dc.contributor.authorGajulapati, Veeraswamy-
dc.contributor.authorGajulapati, Kondaji-
dc.contributor.authorGoo, Ja-Il-
dc.contributor.authorPark, Yeon-Hwa-
dc.contributor.authorJung, Hwa Young-
dc.contributor.authorLee, Sung Yoon-
dc.contributor.authorChoi, Jung Ho-
dc.contributor.authorKim, Young Kook-
dc.contributor.authorLee, Kyeong-
dc.contributor.authorHeo, Tae-Hwe-
dc.contributor.authorChoi, Yongseok-
dc.date.accessioned2024-09-25T03:00:54Z-
dc.date.available2024-09-25T03:00:54Z-
dc.date.issued2016-02-15-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.dongguk.edu/handle/sw.dongguk/23470-
dc.description.abstractA series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 mu M which was much better than (+)-Madindoline A (IC50 = 21 mu M), a known inhibitor of IL-6. (C) 2016 Elsevier Ltd. All rights reserved.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleStructure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2016.01.016-
dc.identifier.scopusid2-s2.0-84958103583-
dc.identifier.wosid000369377700037-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.26, no.4, pp 1282 - 1286-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume26-
dc.citation.number4-
dc.citation.startPage1282-
dc.citation.endPage1286-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusACUTE-PANCREATITIS-
dc.subject.keywordPlusGLYCOPROTEIN 130-
dc.subject.keywordPlusMADINDOLINE-A-
dc.subject.keywordPlusINTERLEUKIN-6-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusANTAGONIST-
dc.subject.keywordPlusGP130-
dc.subject.keywordAuthorRheumatoid arthritis-
dc.subject.keywordAuthorIL-6 antagonists-
dc.subject.keywordAuthorIL-6 signaling inhibitor-
dc.subject.keywordAuthorSTAT3-
dc.subject.keywordAuthorgp130-
dc.subject.keywordAuthorOxazolidinone-
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