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Activation of the phosphatidylinositol 3-kinase/Akt pathway by viral interferon regulatory factor 2 of Kaposi's sarcoma-associated herpesvirus
- Authors
- Kim, Yejin; Cha, Seho; Seo, Taegun
- Issue Date
- 12-Feb-2016
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- KSHV; vIRF2; PI3K/Akt pathway; FOXO3A; Caspase-3
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.470, no.3, pp 650 - 656
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 470
- Number
- 3
- Start Page
- 650
- End Page
- 656
- ISSN
- 0006-291X
1090-2104
- Abstract
- Kaposi's sarcoma-associated herpesvirus encodes several genes with sequence homology to cellular interferon regulatory factors. Among these, vIRF2 encoded by ORF K11.1 (short form) or K11 (full-length) participates in caspase-3-mediated inactivation of cellular IRF3 and slightly inhibits caspase-3 activity. Here, we have demonstrated that vIRF2 attenuates the transcriptional activity of forkhead box O3A protein via activation of the PI3K/Akt phosphatidylinositol 3-kinase/Akt pathway, inhibiting FOXO3A-mediated caspase-3 cleavage. Based on the collective findings, we suggest that vIRF2 acts as an activator in PI3K/Akt pathway. (C) 2016 Elsevier Inc. All rights reserved.
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Related Researcher
- Seo, Tae Gun
- College of Life Science and Biotechnology (Department of Life Science)