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Novel N-(2,2 '-disubstituted-2H-cromenyl)-N ',N ''-disubstituted Guanidine Derivatives as an S-Nitrosoglutathion Reductase Inhibitor
- Authors
- Lee, Gee-Hyung; Nam, Yeonju; Kim, Eun-Mi; Lim, Su-Jeong; Yang, Seung-Ju; Park, Kyuhee; Choi, Yongmun; Gong, Young-Dae
- Issue Date
- Sep-2015
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Anti-inflammatory inhibitor; S-Nitrosoglutathion reductase; Drug-like library; Guanidine derivatives
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.36, no.9, pp 2224 - 2229
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 36
- Number
- 9
- Start Page
- 2224
- End Page
- 2229
- ISSN
- 0253-2964
1229-5949
- Abstract
- Novel N-(2,20-disubstituted-2H-cromenyl)-N0N00-disubstituted guanidine derivatives were synthesized and evaluated as an S-nitrosoglutathion (GSNO) reductase inhibitor. The synthesized guanidine derivatives 1 and 2b showed high potency in an enzyme-based assay with recombinant GSNO reductase (IC50 < 10 mu M). Surface plasmon resonance measurement and molecular docking studies confirmed the direct interaction of compound 2b with GSNO reductase. The results provide valuable information for the design of inhibitors with better spectrum of activity toward GSNO reductase.
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