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Cited 4 time in webofscience Cited 5 time in scopus
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Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica

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dc.contributor.authorNhoek, Piseth-
dc.contributor.authorAhn, Sungjin-
dc.contributor.authorPel, Pisey-
dc.contributor.authorKim, Young-Mi-
dc.contributor.authorHuh, Jungmoo-
dc.contributor.authorKim, Hyun Woo-
dc.contributor.authorNoh, Minsoo-
dc.contributor.authorChin, Young-Won-
dc.date.accessioned2024-08-08T09:31:50Z-
dc.date.available2024-08-08T09:31:50Z-
dc.date.issued2023-01-
dc.identifier.issn0163-3864-
dc.identifier.issn1520-6025-
dc.identifier.urihttps://scholarworks.dongguk.edu/handle/sw.dongguk/20933-
dc.description.abstractFractionation of a methanol extract of Orixa japonica leaves led to the identification of five new quinoline alkaloids (1, 2, 4, 8, and 9), three new coumarins (15, 17, and 19), and 20 known compounds. The structures were determined by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration of 19 was proposed by electronic circular dichroism calculation. Among the compounds tested in the phenotypic screening to measure adiponectin secretion in human bone marrow mesenchymal stem cells, metabolites 4 and 12 stimulated adiponectin secretions with EC50 values of 13.8 and 25.8 mu M, respectively. Further PPARy binding assay and molecular modeling suggested that compounds 4 and 12 are selective PPARy agonists.-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherAmerican Chemical Society-
dc.titleAlkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1021/acs.jnatprod.2c00844-
dc.identifier.scopusid2-s2.0-85144386066-
dc.identifier.wosid000903306700001-
dc.identifier.bibliographicCitationJournal of Natural Products, v.86, no.1, pp 138 - 148-
dc.citation.titleJournal of Natural Products-
dc.citation.volume86-
dc.citation.number1-
dc.citation.startPage138-
dc.citation.endPage148-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusINHIBITORY-ACTIVITIES-
dc.subject.keywordPlusQUINOLINE ALKALOIDS-
dc.subject.keywordPlusACID HYDROPEROXIDE-
dc.subject.keywordPlusMEDICINAL-PLANTS-
dc.subject.keywordPlusFATTY-ACIDS-
dc.subject.keywordPlusANTIBACTERIAL-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusLIGANDS-
dc.subject.keywordPlusALPHA-
dc.subject.keywordAuthorAcetylsalicylic Acid-
dc.subject.keywordAuthorAdiponectin-
dc.subject.keywordAuthorAuraptene-
dc.subject.keywordAuthorBergapten-
dc.subject.keywordAuthorGlibenclamide-
dc.subject.keywordAuthorIsopimpinellin-
dc.subject.keywordAuthorMethoxsalen-
dc.subject.keywordAuthorPentosalen-
dc.subject.keywordAuthorPioglitazone-
dc.subject.keywordAuthorPsoralen-
dc.subject.keywordAuthorResveratrol-
dc.subject.keywordAuthorAdiponectin-
dc.subject.keywordAuthorAlkaloids-
dc.subject.keywordAuthorCoumarins-
dc.subject.keywordAuthorPpar Gamma-
dc.subject.keywordAuthor2',3' Acetyl 3',3' Dimethyl 8 Methoxy 6,7 Dihydropyrano[3,2 G]coumarin-
dc.subject.keywordAuthor3 (3',3' Dimethylallyl) 4,8 Dimethoxy N Methylquinolin 2 One-
dc.subject.keywordAuthor4,8 Dimethoxy 3 (3' Methyl 2' Oxobutyl) 2 Quinolone-
dc.subject.keywordAuthor5 Hydroxy 1 Methyl 2 Phenyl 4 Quinolone-
dc.subject.keywordAuthor5 Hydroxy 6 Methoxy 1 Methyl 2 (4 Methoxyphenyl) 4 Quinolone-
dc.subject.keywordAuthor5 Methoxy 1 Methyl 2 (4 Hydroxyphenyl) 4 Quinolone-
dc.subject.keywordAuthor6,8 Dimethoxy 7 (6' Peroxy 3',7' Dimethyl 2',7' Octadienyloxy)coumarin-
dc.subject.keywordAuthor7 ( 7' Methoxy 3',7' Dimethylocta 2',5' Dienyloxy)coumarin-
dc.subject.keywordAuthor7 (6' Hydroxy 3',7' Dimethyl 2',7' Octadienyloxy)coumarin-
dc.subject.keywordAuthor7 (7' Peroxy 3',7' Dimethylocta 2',5' Dienyloxy) 6,8 Dimethoxycoumarin-
dc.subject.keywordAuthor7 Geranyloxy 6 Methoxycoumarin-
dc.subject.keywordAuthor7 Hydroxy 4,8 Dimethoxy 3 (3 Methylbut 2 Enyl) N Methyl 2 Quinolone-
dc.subject.keywordAuthor7 Hydroxy 4,8 Dimethoxy 3 (3' Methyl But 2' Enyl) 2 Quinolone-
dc.subject.keywordAuthor8alpha Acetoxyelemol-
dc.subject.keywordAuthor8alpha,11 Elemodiol-
dc.subject.keywordAuthorAcetylsalicylic Acid-
dc.subject.keywordAuthorAdiponectin-
dc.subject.keywordAuthorAlkaloid-
dc.subject.keywordAuthorAltissimacoumarin D-
dc.subject.keywordAuthorAuraptene-
dc.subject.keywordAuthorBergapten-
dc.subject.keywordAuthorCoumarin Derivative-
dc.subject.keywordAuthorGlibenclamide-
dc.subject.keywordAuthorIsogosferol-
dc.subject.keywordAuthorIsopimpinellin-
dc.subject.keywordAuthorMethoxsalen-
dc.subject.keywordAuthorN Methylatanine-
dc.subject.keywordAuthorN Methylflindersine-
dc.subject.keywordAuthorOplopanone-
dc.subject.keywordAuthorOrijanone-
dc.subject.keywordAuthorOrixalone B-
dc.subject.keywordAuthorPentosalen-
dc.subject.keywordAuthorPeroxisome Proliferator Activated Receptor Gamma-
dc.subject.keywordAuthorPeroxisome Proliferator Activated Receptor Gamma Agonist-
dc.subject.keywordAuthorPioglitazone-
dc.subject.keywordAuthorPsoralen-
dc.subject.keywordAuthorQuinoline Derivative-
dc.subject.keywordAuthorResveratrol-
dc.subject.keywordAuthorUnclassified Drug-
dc.subject.keywordAuthorArticle-
dc.subject.keywordAuthorBinding Assay-
dc.subject.keywordAuthorBone Marrow Mesenchymal Stem Cell-
dc.subject.keywordAuthorControlled Study-
dc.subject.keywordAuthorDrug Mechanism-
dc.subject.keywordAuthorDrug Screening-
dc.subject.keywordAuthorDrug Structure-
dc.subject.keywordAuthorEc50-
dc.subject.keywordAuthorElectronic Circular Dichroism-
dc.subject.keywordAuthorHuman-
dc.subject.keywordAuthorHuman Cell-
dc.subject.keywordAuthorMolecular Model-
dc.subject.keywordAuthorNonhuman-
dc.subject.keywordAuthorNuclear Magnetic Resonance Spectroscopy-
dc.subject.keywordAuthorOrixa Japonica-
dc.subject.keywordAuthorPlant Leaf-
dc.subject.keywordAuthorRutaceae-
dc.subject.keywordAuthorStructure Analysis-
dc.subject.keywordAuthorChemical Structure-
dc.subject.keywordAuthorChemistry-
dc.subject.keywordAuthorAdiponectin-
dc.subject.keywordAuthorAlkaloids-
dc.subject.keywordAuthorCoumarins-
dc.subject.keywordAuthorHumans-
dc.subject.keywordAuthorMolecular Structure-
dc.subject.keywordAuthorPlant Leaves-
dc.subject.keywordAuthorPpar Gamma-
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