Intramolecular Mizoroki-Heck Reaction of 2-Thiosubstituted Acrylates for the Synthesis of 3-Substituted Benzo[b]thiophene-2-carboxylates

Abstract

3-Substituted 2-(phenylthio) acrylates prepared from aldol condensation using titanium tetrachloride were employed to synthesize benzo[b]thiophenes. The acrylates containing aryls and alkyls generated the desired benzo[b]thiophenes in reasonable yields under the optimized Heck condition, but acrylates having heteroaryls gave the desired products in poor yields or no products under the condition.