Heterostructured Layered Aluminosilicate-Itraconazole Nanohybrid for Drug Delivery System

Abstract

A nanohybrid, consisting of layered aluminosilicate as a host material and itraconazole as a guest molecule, was successfully synthesized through the interfacial intercalation reaction across the boundary between water and water-immiscible liquid at the various pH. According to the powder X-ray diffraction pattern, the basal spacing of the intraconazole-layered aluminosilicate nanohybrid increased from 14.7 to 22.7 angstrom depending on the pH of the aqueous suspension. The total amounts of itraconazole in the hybrids were determined to be 2.3 similar to 25.4 wt% by HPLC analysis. The in vivo pharmacokinetics study was performed in rats in order to compare the absorptions of itraconazole for the itraconazole-layered aluminosilicate nanohybrid and a commercial product, Sporanox (R). The pharmacokinetic data for the hanohybrid and Sporanox (R) showed that the mean area under the plasma concentration-time curve (AUC, 2477 +/- 898 ng.hr/mL and 2630 +/- 953 ng.hr/mL, respectively) and maximum concentration (C-max, 225.4 +/- 77.4 ng.hr/mL and 223.6 +/- 51.9 ng.hr/mL, respectively), were within the bioequivalence (BE) range. Therefore, we concluded that this drug-layered aluminosilicate nanohybrid system has a great potential for its application in formulation of poorly soluble drugs.