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Discovery of a Novel 2,6-Difunctionalized 2H-Senzopyran Inhibitors Toward Sphingosylphosphorylcholine Synthetic Pathway as New Anti-inflammatory Target

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dc.contributor.authorLee, Gee-Hyung-
dc.contributor.authorLee, Seong Jin-
dc.contributor.authorJeong, Dae Young-
dc.contributor.authorKim, Ha-Young-
dc.contributor.authorLee, Doohyun-
dc.contributor.authorLee, Taeho-
dc.contributor.authorHwang, Jong-Yeon-
dc.contributor.authorPark, Woo Kyu-
dc.contributor.authorKong, Jae-Yang-
dc.contributor.authorCho, Heeyeong-
dc.contributor.authorGong, Young-Dae-
dc.date.accessioned2024-08-08T01:31:23Z-
dc.date.available2024-08-08T01:31:23Z-
dc.date.issued2014-08-20-
dc.identifier.issn0253-2964-
dc.identifier.issn1229-5949-
dc.identifier.urihttps://scholarworks.dongguk.edu/handle/sw.dongguk/15315-
dc.description.abstractNovel 2,6-difuctionalized 2H-benzopyrans were synthesized and evaluated for a sphingosylphosphorylcholine (SPC) inhibitor. The synthetic 2H-benzopyrans 1c and 3a showed high potency in SPC-induced cell proliferation assay (IC50 < 20 nM). Neither hERG K+ channel binding (> 10 mu M) nor CYP inhibitions (> 10 mu M) were observed. Also, the simple structure-activity relationship (SAR) results were obtained from analysis of 2H-benzopyran derivatives 1-3 and the anti-SPC effect of 2H-benzopyran 1c was confirmed by a HUVEC tube formation assay.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleDiscovery of a Novel 2,6-Difunctionalized 2H-Senzopyran Inhibitors Toward Sphingosylphosphorylcholine Synthetic Pathway as New Anti-inflammatory Target-
dc.typeArticle-
dc.publisher.location독일-
dc.identifier.doi10.5012/bkcs.2014.35.8.2385-
dc.identifier.scopusid2-s2.0-84906342349-
dc.identifier.wosid000340690600028-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.8, pp 2385 - 2390-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume35-
dc.citation.number8-
dc.citation.startPage2385-
dc.citation.endPage2390-
dc.type.docTypeArticle-
dc.identifier.kciidART001897385-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusPHASE PARALLEL SYNTHESIS-
dc.subject.keywordPlusN-ACYL LINKAGE-
dc.subject.keywordPlusATOPIC-DERMATITIS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusGLUCOSYLCERAMIDE-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusDEACYLASE-
dc.subject.keywordPlusLIBRARY-
dc.subject.keywordPlusENZYME-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorSphingosylphosphorylcholine-
dc.subject.keywordAuthorAnti-inflammatory inhibitors-
dc.subject.keywordAuthorDrug-like library-
dc.subject.keywordAuthor2H-benzopyran-
dc.subject.keywordAuthorSmall molecules-
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